ABSTRACT
Polycystic ovary syndrome(PCOS)is a syndrome of multiple etiological factors and clinical manifestations.It's essential pathophysiological signs are chronic anovulatory and hyperandrogenism.Recent studies have dominated that PCOS is an endocrine metabolic disease characterized by insulin resistance(IR)and is a component of Metabolism syndrome(MS).Several factors related to MS and the ultima angiocardiopathy change exist in PCOS.
ABSTRACT
Objective To study the assiociation of-866G/A polymorphism in the promoter of uncoupling protein 2(UCP2)gene in patients with type 2 diabetes and B-cell function in Han population in Nanjing.Methods For the case-control study,PCR-RFLP method was used to determine the distributions of allele and genotype frequencies of-866G/A polymorphism in the human UCP2 gene in 229 type 2 diabetic patients and 196 normal control subjects.All of the testees accepted oral glucose tolerance test and insulin releasing test to detect B-cell secretion function and insulin sensitivity.Results The distribution of genotype and allele frequencies of-866G/A polymorphism in the promoter of the human UCP2 gene were significantly different between type 2 diabetic patients and normal control subjects(?2=6.555,P=0.038;?2=6.363,P=0.012 respectively).The frequency of A/A genotype and A allele in type 2 diabetic were significantly higher than that in contrast(OR=1.99,OR=1.42 respectively,both P
ABSTRACT
Polycystic ovary syndrome (PCOS) is of multiple etiological factors and clinical manifestations characterized by chronic anovulation and hyperandrogenism. A great deal of studies confirm that insulin resistance (IR) might be one of the mechanisms in the development of PCOS. This article reviews the pathogenesis of IR in PCOS.